IFN alpha-IFNAR-IN-1 hydrochloride

Research use only, not for human use.

IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 μM.

IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 μM.(In Vitro):IFN alpha-IFNAR-IN-1 hydrochloride inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 hydrochloride specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 hydrochloride exerts immunosuppressive activity by the direct interaction with IFN-α.

IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs.

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Others

Other Targets

antimalarial

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2070014-98-9

315.86

C18H18ClNS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (316.60 mM)

Cl.CNCc1ccccc1Sc1cccc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years